Friday, September 8, 2006, marks the twentieth anniversary of the Oprah Winfrey Show.

The program entered national syndication in the USA on September 8, 1986. "Oprah" would eventually become the highest-rated talk show in television history.

In 1988, Winfrey established Harpo Studios, a production facility in Chicago, Illinois. She was the third woman in the American entertainment industry (after Mary Pickford and Lucille Ball) to own her own studio.

The Oprah Winfrey Show is seen by an estimated 49 million viewers a week in the United States, and is broadcast internationally in 122 countries.